China (Mainland)
Best price Nilotinib 641571-10-0 certified factory with fast delivery CAS NO.641571-10-0
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 1 Gram
- Payment Terms: T/T,
- Available Specifications:
1(1-10)Gram
- Product Details
Keywords
- Erlotinib
- 183321-74-6
- Nilotinib factory
Quick Details
- ProName: Best price Nilotinib 641571-10-0 certi...
- CasNo: 641571-10-0
- Molecular Formula: C28H22F3N7O
- Appearance: White crystallized powder
- Application: medical
- DeliveryTime: within 7 working days
- PackAge: al foil bag
- Port: shanghai
- ProductionCapacity: 1000 Kilogram/Month
- Purity: 99% min
- Storage: Kept in a well-closed, light-resistan...
- Transportation: Kept in a well-closed, light-resistan...
- LimitNum: 1 Gram
- Molecular Formula: C28H22F3N7O
- Impurity: 0.05%
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1, High quality with competitive price:
1)Purity≥ 99%
2)We are manufacturer and can provide high quality products with factory price,offering free samples to test, a few shipping fee only.
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3)Secure and discreet shipment. Various transportation methods for your choice.
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5)We have special way could ship 0.01kg to sveral kg products a time. We offer melting powder into liquid service. And ship the liquid in special bottles.
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2)we will teach you recipes and instructions for all kind of steroid to turn powder into liquid, and liquid become sterile ones.
Details
Details
Best price Nilotinib 641571-10-0 certified factory with fast delivery
Quick Details:
|
Product Name |
Nilotinib |
|
Molecular Formula |
C28H22F3N7O |
|
Molecular Weight |
529.53 |
|
Storage |
3years in -20ºC |
|
Targets |
Bcr-Abl |
|
IC50 |
30 nM |
|
IC50 |
/ |
|
Dosage |
Oral administration, 75 mg/kg, daily |
Product Name: Nilotinib
Other Name:Nilotinib;AMN 107;Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-;4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4 -pyridin-3-ylpyrimidin-2-yl)amino]benzamide;Nilotinib(TINIBS );4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide;Nilotinib for research;Tasigna
Model No.: ATC-142
CAS No.: 641571-10-0
Molecular Formula: C28H22F3N7O
Molecular Weight:529.52
Stability: N/A
Target:N/A
Appearance: Off-White Solid
Melting Point: N/A
Purity: 99%+
Suitable People: ALl
Product Specifications: Pharmaceutical Grade
Standard: Qualified
MOQ(Minimum Order Quantity): 10g
Payment: L/C, T/T,
Shipment: EMS, DHL, FedEx, TNT
Packing: Aluminium Foil Bag or as Required
Brand: Biocar
Origion: Hubei,China
Export Markets: Global
Product Description
Nilotinib is a selective, oral inhibitor of tyrosine kinase with IC50 values of 20, 42, 31, 38, 29 and 41 nM for the autophosphorylation of native BCR-ABL (WT p210) and mutant BCR-ABL (E281K, E292K, F317L, M351T and F486S), respectively.
Nilotinib was designed based on the structure of imatinib and showed the superiority over imatinib in newly diagnosed or imatinib-resistant chronic myelogenous leukemia (CML). It was more potent than imatinib to wild-type BCR-ABL in a wide range of CML-derived and transfected cell lines. Nilotinib was also efficacious in gastrointestinal stromal tumors. Nilotinib showed inhibition activities in KIT mutant cells, including KITV560del, KITK642E and KITV560G (IC50 value of 108 nM). It also was effect to double mutations of KIT, such as KITV560del/V654A, KITV559D/D820Y, KITV560del/V654A (IC50: 192 nM) and KITV559D/D820Y (IC50: 297 nM). Besides that, Nilotinib exerted selective inhibition of PDGFRα and PDGFRβ. It suppressed cell proliferation with IC50 value of 0.54 nM in EOL-1 cells with constitutive activation of FIP1L1-PDGFRα.
Nilotinib is an anti-cancer medication that is used to treat some types of leukemia, specifically Philadelphia chromosome positive chronic myeloid leukemia (Ph + CML). This medication is called a kinase inhibitor, which means that it works to halt the growth and spread of cancer cells. Nilotinib accomplishes this by inhibiting an abnormal protein that is responsible for instructing cancer cells to multiply. With this particular type of cancer, the body manufactures a great deal of abnormal white blood cells. Nilotinib is only prescribed after other cancer treatments, such as imatinib, have been tried and have not been sufficient.
Nilotinib (AMN107, trade name Tasigna), in the form of the hydrochloride monohydrate salt, is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia. Structurally related to imatinib, it was developed based on the structure of the Abl-imatinib complex to address imatinib intolerance and resistance. Nilotinib is a selective Bcr-Abl kinase inhibitor that is 10-30 fold more potent than imatinib in inhibiting Bcr-Abl tyrosine kinase activity and proliferation of Bcr-Abl expressing cells.
Description:
This peptide hormone, called alpha-Melanocyte stimulating hormone or MSH, activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors. As a result, Melanotan 2 has been shown in studies to exhibit appetite suppressant, lipolytic, and libido-enhancing effects in addition to promoting skin tanning.
Applications:
Testosterone Acetate combination of Testosterone and ester acetate, Testosterone Acetate is an androgenic steroide with a pronounced anabolic effect. Most acetate treatments deliver medication to the body relatively quickly.
Testosterone Acetate has very low risk of water retention. Individuals that utilize this form of Testosterone also claim that it is arguably the most painless form of Testosterone. Testosterone Acetate ester is much faster acting, and thus requires a more frequent schedule in order to keep blood levels as stable as possible.
Testosterone Acetate Results of Analysis:
|
Test Items |
Specification |
Test Results |
|
Appearance |
White or almost white crystalline powder |
white crystalline powder |
|
Loss on drying |
≦0.5% |
0.34% |
|
Melting point |
139-141 °C |
139-140 °C |
|
(HPLC)Assay |
97-103.0% |
99.08% |
|
Free acid |
0.5%max |
0.31% |
|
Conclusion |
The aboye product conforms analysis standard |
Conform |
